![]() ![]() Poisonings Ītropine is not an actual antidote for organophosphate poisoning. Even though atropine has not been officially indicated for either of these purposes by the FDA, it has been used by physicians for these purposes. This can be useful in treating hyperhidrosis, and can prevent the death rattle of dying patients. The drug may also inhibit sweating via the sympathetic nervous system. Secretions Ītropine's actions on the parasympathetic nervous system inhibit salivary and mucus glands. Ītropine has also been used in an effort to prevent a low heart rate during intubation of children however, evidence does not support this use. It is usually not effective in second-degree heart block Mobitz type 2, and in third-degree heart block with a low Purkinje or ventricular escape rhythm. Ītropine is also useful in treating second-degree heart block Mobitz type 1 (Wenckebach block), and also third-degree heart block with a high Purkinje or AV-nodal escape rhythm. For symptomatic bradycardia, the usual dosage is 0.5 to 1 mg IV push, may repeat every 3 to 5 minutes up to a total dose of 3 mg (maximum 0.04 mg/kg). Injections of atropine are used in the treatment of symptomatic or unstable bradycardia.Ītropine was previously included in international resuscitation guidelines for use in cardiac arrest associated with asystole and PEA, but was removed from these guidelines in 2010 due to a lack of evidence for its effectiveness. The lower dose of 0.01% is thus generally recommended due to fewer side effects and potential less rebound worsening when the atropine is stopped. All doses of atropine appear similarly effective, while higher doses have greater side effects. ![]() Īntimuscarinic topical medication is effective in slowing myopia progression in children accommodation difficulties and papillae and follicles are possible side-effects. ![]() Evidence suggests that atropine penalization is just as effective as occlusion in improving visual acuity. In refractive and accommodative amblyopia, when occlusion is not appropriate sometimes atropine is given to induce blur in the good eye. Atropine degrades slowly, typically wearing off in 7 to 14 days, so it is generally used as a therapeutic mydriatic, whereas tropicamide (a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic agonist) is preferred as an aid to ophthalmic examination. Topical atropine is used as a cycloplegic, to temporarily paralyze the accommodation reflex, and as a mydriatic, to dilate the pupils. Medical uses Īn ampoule containing atropine injection 0.5mg/1mL Eyes It was first isolated in 1833, It is on the World Health Organization's List of Essential Medicines. Ītropine occurs naturally in a number of plants of the nightshade family, including deadly nightshade (belladonna), Jimson weed, and mandrake. It is an antimuscarinic (a type of anticholinergic) that works by inhibiting the parasympathetic nervous system. While there is no evidence that its use during pregnancy causes birth defects, this has not been well studied so sound clinical judgment should be used. It should generally not be used in people with closed-angle glaucoma. Ĭommon side effects include dry mouth, abnormally large pupils, urinary retention, constipation, and a fast heart rate. Large doses may be required to treat some poisonings. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Eye drops are also available which are used to treat uveitis and early amblyopia. It is typically given intravenously or by injection into a muscle. Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. ![]()
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